![]() Human retinal development: Ultrastructure of the outer retina. in Proceedings of the 6th ISCERG symposium. Ontogenesis of the electroretinogram in a precocial mammal, the guinea pig ( Cavia porcellus). Zur postnatalen Entwicklung der Netzhautfunktion. Invest Ophthalmol Vis Sci 1998 39: S132.īornschein VH. Maturation of the oscillatory potentials gradually shapes the unique morphology of the guinea pig's ERG. J Lipid Res 1998 39: 1274–1279.ĭassa J, Behn D, Casanova C, Lachapelle P. Effect of diet on the rate of depletion of n-3 fatty acids in the retina of the guinea pig. Spectral sensitivity, photopigments, and color vision in the guinea pig ( Cavia porcellus). Retinal function in rats and guinea pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. Leat WMF, Curtis R, Millichamp NJ, Cox RW. The a-wave of the human ERG and rod receptor function. Furthermore, decreased Rm P3 and log S with age is observed in the pigmented group only and is consistent with increased ocular resistance due to melanin development in this strain. Whereas the larger Rm P3, even after allowing for increased light effectiveness, may reflect a lower ocular resistance in albino eyes due to their lower levels of melanin. We argue that the likely cause for the larger log S of albino eyes is compatible with theories of increased levels of internal light. Whereas the adult values of log S implies a mature phototransduction process at birth. Maturation of Rm P3 implies a postnatal increase in rod outer segment length. Guinea pigs have significant postnatal development in their receptoral response. Albino animals had significantly ( p<0.05) larger Rm P3 and log S across all ages. Receptoral delay (t d) also undergoes some postnatal maturation, while phototransduction gain (log S) is adult-like at birth. Guinea pigs show saturated amplitudes (Rm P3) that are 50% of adult values at birth, these mature by PD12. Receptoral components were modelled using the delayed gaussian model of Hood and Birch fitted as an ensemble to the raw data. A-wave amplitudes and implicit times were extracted from filtered data (0–75 Hz). Electroretinograms were collected on groups of albino and pigmented animals from postnatal day (PD) PD1 to PD60. In addition, the time course and nature of maturation was compared between albino and pigmented strains to consider the role that melanogenesis might have in this process. We describe the postnatal development of the electroretinogram (ERG) receptoral response in the guinea pig.
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